Pre_GI Gene

Some Help

Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:16465 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16465177751311polyA polymeraseQuickGO ontologyBLASTP
1826518471207hypothetical proteinBLASTP
1857419302729DNA translocation competence proteinQuickGO ontologyBLASTP
1932319469147hypothetical proteinBLASTP
20189257895601cell surface antigenQuickGO ontologyBLASTP
2607126175105hypothetical proteinBLASTP
2653726662126hypothetical proteinBLASTP
2710727847741hypothetical proteinBLASTP
2781428047234hypothetical proteinBLASTP
2818828370183hypothetical proteinBLASTP
2870229196495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2919629669474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2968829912225F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
3010830836729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
3084131104264hypothetical proteinBLASTP
3121532048834protein-disulfide isomeraseQuickGO ontologyBLASTP
3221232733522transcriptional regulatorQuickGO ontologyBLASTP
32980345841605methyltransferaseQuickGO ontologyBLASTP
3470734916210hypothetical proteinBLASTP
35013360951083recombination protein FQuickGO ontologyBLASTP