Pre_GI Gene

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Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:100000 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
100264100824561putative cytoplasmic proteinQuickGO ontologyBLASTP
1008791022761398NADp transhydrogenase subunit betaQuickGO ontologyBLASTP
102415103149735OmpW family outer-membrane proteinQuickGO ontologyBLASTP
103304104188885transporter drugmetabolite exporter family proteinQuickGO ontologyBLASTP
1041751054311257MFS superfamily transporterQuickGO ontologyBLASTP
105428105604177hypothetical proteinBLASTP
105712105912201hypothetical proteinBLASTP
106266106568303preprotein translocase subunit SecGQuickGO ontologyBLASTP
107282107419138hypothetical proteinBLASTP
1074751129615487hypothetical proteinBLASTP
1132581146371380cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
11487811576588830S ribosomal protein S2QuickGO ontologyBLASTP
115964116893930elongation factor TsQuickGO ontologyBLASTP
117367117756390hypothetical proteinBLASTP
118126118254129hypothetical proteinBLASTP
11840311979713953-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
119794120450657hypothetical proteinBLASTP
1206011218061206aspartate aminotransferaseQuickGO ontologyBLASTP
12200012207778hypothetical proteinBLASTP