Pre_GI Gene

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Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:230000 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
230075230236162hypothetical proteinBLASTP
2310972322991203coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
23239323249199hypothetical protein
232521232862342hypothetical proteinBLASTP
232924233055132hypothetical proteinBLASTP
233470233652183hypothetical proteinBLASTP
233977234165189hypothetical proteinBLASTP
2342162354151200protonsodium-glutamate symport proteinQuickGO ontologyBLASTP
235454235768315divalent cation tolerance proteinQuickGO ontologyBLASTP
2357712361874176-carboxy-5678-tetrahydropterin synthaseQuickGO ontologyBLASTP
2363582375451188dihydrolipoamide succinyltransferaseQuickGO ontologyBLASTP
237560237712153hypothetical proteinBLASTP
23770924049527872-oxoglutarate dehydrogenase E1 componentQuickGO ontologyBLASTP
2406312421211491thermostable carboxypeptidaseQuickGO ontologyBLASTP
2421872438241638DNA repair protein RecNQuickGO ontologyBLASTP
243832244587756ComL family lipoproteinQuickGO ontologyBLASTP
244866245045180cation transport regulatorQuickGO ontologyBLASTP
2451242462451122chaperone protein DnaJQuickGO ontologyBLASTP
2463742482571884molecular chaperone DnaKQuickGO ontologyBLASTP
2483192498121494endopeptidaseQuickGO ontologyBLASTP