Pre_GI Gene

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Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:771542 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7715427728761335DNA repair protein RadAQuickGO ontologyBLASTP
772873773187315hypothetical proteinBLASTP
773309774022714DNA repair protein RecOQuickGO ontologyBLASTP
774174774323150hypothetical proteinBLASTP
774540775232693glycoprotease family proteinQuickGO ontologyBLASTP
7752897765511263hypothetical proteinBLASTP
7769187794132496translation initiation factor IF-2QuickGO ontologyBLASTP
7796517811621512transcription elongation factor NusAQuickGO ontologyBLASTP
781173781658486ribosome maturation protein RimPQuickGO ontologyBLASTP
781832782188357hypothetical proteinBLASTP
782710783108399hypothetical proteinBLASTP
783176783604429Rrf2 family proteinQuickGO ontologyBLASTP
783599784354756hemolysinQuickGO ontologyBLASTP
7845137857481236tyrosyl-tRNA synthetaseQuickGO ontologyBLASTP
785752785994243hypothetical proteinBLASTP
786041786292252hypothetical proteinBLASTP
786360786617258hypothetical proteinBLASTP
786784786996213hypothetical proteinBLASTP
788015788230216hypothetical proteinBLASTP
788436788915480hypothetical proteinBLASTP
790031790231201hypothetical proteinBLASTP
790230790442213hypothetical proteinBLASTP
791296791526231prolinebetaine transporterQuickGO ontologyBLASTP