Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_002755: Mycobacterium tuberculosis CDC1551, complete genome

NCBI: NC_002755

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
147287249645723586Island text1.8045717.035518.766Neighbours11BLASTN+472872.gbk
283139785005418658Island text1.6686115.433521.1049Neighbours11BLASTN+IslandViewer 831397.gbk
31095105*111578720683Island text1.58518.85724.9702Neighbours11BLASTN+IslandViewer 1095105.gbk
41684161170880524645Island text1.9789421.980921.5891Neighbours11BLASTN+IslandViewer 1684161.gbk
51859630187892619297Island text1.5980715.573326.9765Neighbours11BLASTN1859630.gbk
62788000281039922400Island text1.4715620.093622.4997Neighbours11BLASTN2788000.gbk
73110929312975718829Island text1.5254720.168632.4826Neighbours11BLASTN+IslandViewer 3110929.gbk
83282785330371920935Island text1.5314616.475231.396Neighbours11BLASTN+3282785.gbk
93465582349023924658Island text1.5152118.500718.5345NeighboursBLASTN+3465582.gbk
103773734379844824715Island text1.5763418.895928.4018Neighbours11BLASTN+IslandViewer 3773734.gbk