Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:2788000 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27880382788208171hypothetical proteinBLASTP
278821127894761266carboxylesterase family proteinQuickGO ontologyBLASTP
27898382790608771enoyl-CoA hydrataseQuickGO ontologyBLASTP
279078927928732085PE_PGRS family proteinQuickGO ontologyBLASTP
279295527962963342transcriptional regulator LuxR familyQuickGO ontologyBLASTP
27963342796696363hypothetical proteinBLASTP
279674228017394998PE_PGRS family proteinQuickGO ontologyBLASTP
28018112802017207hypothetical proteinBLASTP
28021532802776624hypothetical proteinBLASTP
28027662803518753hypothetical proteinBLASTP
28035712803792222hypothetical proteinBLASTP
28037982804223426hypothetical proteinBLASTP
280424628054271182dihydrolipoamide acetyltransferaseQuickGO ontologyBLASTP
2805424280647010472-oxoisovalerate dehydrogenase E1 component beta subunit putativeQuickGO ontologyBLASTP
2806481280758411042-oxoisovalerate dehydrogenase E1 component alpha subunit putativeQuickGO ontologyBLASTP
28078432808664822citrate lyase beta subunitQuickGO ontologyBLASTP
28086612809218558MoaC family proteinQuickGO ontologyBLASTP
280921528103991185acyl-CoA dehydrogenaseQuickGO ontologyBLASTP