Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:472872 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4728724741971326hypothetical proteinBLASTP
474213474932720hypothetical protein
475031475435405hypothetical proteinBLASTP
475417475833417hypothetical proteinBLASTP
475874476344471hypothetical proteinBLASTP
476485476733249hypothetical proteinBLASTP
476770477411642hypothetical proteinBLASTP
4774184786471230lipoprotein putativeQuickGO ontologyBLASTP
4786574798471191glutaryl-CoA dehydrogenase putativeQuickGO ontologyBLASTP
479880480251372hypothetical proteinBLASTP
4804464833222877membrane protein MmpL familyQuickGO ontologyBLASTP
483432484316885IS6110 transposaseQuickGO ontologyBLASTP
484367484693327IS6110 hypothetical proteinQuickGO ontologyBLASTP
484650485105456hypothetical proteinBLASTP
485313485426114hypothetical protein
4854264871831758acyl-CoA synthaseQuickGO ontologyBLASTP
4871804913884209polyketide synthaseQuickGO ontologyBLASTP
491336492094759metallo-beta-lactamase superfamily proteinQuickGO ontologyBLASTP
4922324932421011glucose-6-phosphate dehydrogenase F420-dependentQuickGO ontologyBLASTP
4932354953072073phosphate acetyltransferaseQuickGO ontologyBLASTP
4953004964571158acetatepropionate kinaseQuickGO ontologyBLASTP