Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:1684161 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
168416116864132253methylmalonyl-CoA mutaseQuickGO ontologyBLASTP
16864271686729303hypothetical proteinBLASTP
16867261687043318hypothetical proteinBLASTP
168704016880441005arginineornithine transport system ATPaseQuickGO ontologyBLASTP
168810016893861287esteraseQuickGO ontologyBLASTP
16894591690076618methyltransferaseQuickGO ontologyBLASTP
16902901690502213hypothetical proteinBLASTP
16904911690961471hypothetical proteinBLASTP
169100616920341029dolichol-phosphate mannosyltransferase putativeQuickGO ontologyBLASTP
16920461692867822mmcH protein putativeQuickGO ontologyBLASTP
16930801693979900hypothetical proteinBLASTP
16954371696102666transferase putativeQuickGO ontologyBLASTP
16960991696617519hypothetical proteinBLASTP
16968831697578696hypothetical proteinBLASTP
16975121698015504hypothetical proteinBLASTP
169825117000501800hypothetical proteinBLASTP
17002241700364141hypothetical protein
17003681701249882hypothetical proteinBLASTP
17014511701969519hypothetical proteinBLASTP
17019781702748771hypothetical proteinBLASTP
17027521703171420hypothetical proteinBLASTP
170320517042511047GDP-D-mannose dehydrataseQuickGO ontologyBLASTP
170420017052161017fucose synthetaseQuickGO ontologyBLASTP
17052131705944732hypothetical proteinBLASTP
17059621706750789glycosyl transferaseQuickGO ontologyBLASTP
17067851707771987hypothetical proteinBLASTP
170768417088051122glycosyl transferaseQuickGO ontologyBLASTP