Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:3282785 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
328278532840261242IS1533 transposase protein AQuickGO ontologyBLASTP
32841113284827717IS1533 transposase protein BQuickGO ontologyBLASTP
32849453285646702lipoprotein putativeQuickGO ontologyBLASTP
328582432906864863polyketide synthaseQuickGO ontologyBLASTP
329067132921611491polyketide synthaseQuickGO ontologyBLASTP
329215832942752118acyl-CoA synthaseQuickGO ontologyBLASTP
32942923294930639hypothetical proteinBLASTP
329491732966651749acyl-CoA synthaseQuickGO ontologyBLASTP
32969363297253318hypothetical protein
329742432985691146N5N10-methylenetetrahydromethanopterin reductase-related proteinQuickGO ontologyBLASTP
32987623299574813methyltransferase putativeQuickGO ontologyBLASTP
329960033008561257hypothetical proteinBLASTP
33009873301586600hypothetical proteinBLASTP
33019003302874975hypothetical proteinBLASTP
33029883303719732hypothetical proteinBLASTP