Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:3465582 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34655823466475894cell division protein FtsXQuickGO ontologyBLASTP
34664763467165690cell division ATP-binding proteinQuickGO ontologyBLASTP
34672093467685477hypothetical protein
34676483468574927hypothetical proteinBLASTP
346856434696791116peptide chain release factor 2QuickGO ontologyBLASTP
346980434711741371ferredoxin--NADP reductaseQuickGO ontologyBLASTP
347117534727581584alkyl-dihydroxyacetonephosphate synthase putativeQuickGO ontologyBLASTP
34727883473297510hypothetical proteinBLASTP
347341934745251107molybdopterin cofactor biosynthesis protein AQuickGO ontologyBLASTP
34745433474971429pterin-4-alpha-carbinolamine dehydrataseQuickGO ontologyBLASTP
34749683475480513molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
34754973475748252molybdenum cofactor biosynthesis protein DQuickGO ontologyBLASTP
34758713476539669hydrolase haloacid dehalogenase-like familyQuickGO ontologyBLASTP
34765233477086564cytidine and deoxycytidylate deaminase family proteinQuickGO ontologyBLASTP
347718534784951311IS1081 transposaseQuickGO ontologyBLASTP
347857334797421170HesAMoeBThiF family proteinQuickGO ontologyBLASTP
34797713480604834thiosulfate sulfurtransferaseQuickGO ontologyBLASTP
34806063480908303hypothetical proteinBLASTP
34809293481372444molybdopterin cofactor biosynthesis protein EQuickGO ontologyBLASTP
34813693481971603hypothetical proteinBLASTP
348230634835081203P450 heme-thiolate proteinQuickGO ontologyBLASTP
34835903483823234hypothetical proteinBLASTP
34838863484356471hypothetical proteinBLASTP
34843813484860480hypothetical proteinBLASTP
34849663485106141hypothetical proteinBLASTP
34852373486172936transcriptional regulator AfsRDnrIRedD familyQuickGO ontologyBLASTP
348627334874481176PPE family proteinQuickGO ontologyBLASTP
34874993487663165hypothetical protein
34876053487919315hypothetical proteinBLASTP
348793234889781047hypothetical proteinBLASTP