Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:1095105 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109510510965351431PE_PGRS family proteinQuickGO ontologyBLASTP
10968551097547693DNA-binding response regulatorQuickGO ontologyBLASTP
109754710990611515sensor histidine kinaseQuickGO ontologyBLASTP
109915911004991341heat shock protein HtrA putativeQuickGO ontologyBLASTP
11004961101044549molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
11010641101519456large-conductance mechanosensitive channelQuickGO ontologyBLASTP
11018421102588747ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
110258111051482568hypothetical proteinBLASTP
110515511063151161hypothetical proteinBLASTP
110644411074451002polyprenyl synthetaseQuickGO ontologyBLASTP
11074821108138657hypothetical proteinBLASTP
11082111108564354hypothetical proteinBLASTP
110861711092045885-formyltetrahydrofolate cyclo-ligase-related proteinQuickGO ontologyBLASTP
11093111110231921UTP--glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
111030811115881281molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
11116511112262612ribosomal-protein-alanine acetyltransferaseQuickGO ontologyBLASTP
111232411134991176hypothetical proteinBLASTP
11136731113813141hypothetical proteinBLASTP
11138991114150252hypothetical proteinBLASTP
11142111114420210hypothetical proteinBLASTP
11144991114762264hypothetical proteinBLASTP
11148371115787951cyclic nucleotide-binding proteinQuickGO ontologyBLASTP