Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:831397 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
831397831894498transcriptional regulator MarR familyQuickGO ontologyBLASTP
831891832103213hypothetical protein
832252832800549hypothetical proteinBLASTP
833045833851807hypothetical proteinBLASTP
833885834133249hypothetical proteinBLASTP
834130834492363hypothetical proteinBLASTP
834723835037315IS1557 transposaseQuickGO ontologyBLASTP
835179835697519PE_PGRS family proteinQuickGO ontologyBLASTP
835866836006141hypothetical protein
836075836632558hypothetical proteinBLASTP
836629837168540hypothetical proteinBLASTP
837248837394147hypothetical proteinBLASTP
837343837870528hypothetical proteinBLASTP
8378908402412352PE_PGRS family proteinQuickGO ontologyBLASTP
840318840560243hypothetical protein
8406408429972358PE_PGRS family proteinQuickGO ontologyBLASTP
843079843345267hypothetical proteinBLASTP
843369843797429hypothetical proteinBLASTP
843878844015138hypothetical proteinBLASTP
844150844419270hypothetical proteinBLASTP
8444888453728853-hydroxyisobutyrate dehydrogenaseQuickGO ontologyBLASTP
8453838465551173acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
8465628480941533methylmalonic acid semialdehyde dehydrogenaseQuickGO ontologyBLASTP
8483008500541755PE_PGRS family proteinQuickGO ontologyBLASTP