Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:3110929 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31109293111465537hypothetical proteinBLASTP
311153631129451410IS1604 transposaseQuickGO ontologyBLASTP
31129423113754813general secretion pathway protein A-related proteinQuickGO ontologyBLASTP
31153553116239885IS6110 transposaseQuickGO ontologyBLASTP
31162903116616327IS6110 hypothetical proteinQuickGO ontologyBLASTP
31178303118171342CRISPR-associated protein Cas2QuickGO ontologyBLASTP
311817231191881017CRISPR-associated protein Cas1QuickGO ontologyBLASTP
311920131204931293hypothetical proteinBLASTP
312044531215721128CRISPR-associated TM1807 family proteinQuickGO ontologyBLASTP
31215693122477909CRISPR-associated TM1808 family proteinQuickGO ontologyBLASTP
31224583123168711CRISPR-associated TM1792 family proteinQuickGO ontologyBLASTP
31231783123552375CRISPR-associated TM1810 family proteinQuickGO ontologyBLASTP
312354931260022454CRISPR-associated TM1811 family proteinQuickGO ontologyBLASTP
31259843126928945hypothetical proteinBLASTP
31271063127846741hypothetical proteinBLASTP
31279233128813891hypothetical proteinBLASTP
31288103129757948hypothetical proteinBLASTP