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Query: NC_018939:454000:473403 Helicobacter pylori 26695 chromosome, complete genome

Start: 473403, End: 474071, Length: 669

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:453958:473368473368474066699Helicobacter pylori 26695, complete genomehypothetical protein4e-130463
NC_012973:967380:971047971047971931885Helicobacter pylori B38 chromosome, complete genome3e-100364
NC_017379:996500:99925899925810011081851Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein1e-97355
NC_017378:986611:990454990454991200747Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein2e-95348
NC_017355:997089:1000599100059910022631665Helicobacter pylori v225d chromosome, complete genomehypothetical protein6e-56217
NC_017362:992293:996466996466996900435Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein2e-40165
NC_017355:997089:100218710021871002456270Helicobacter pylori v225d chromosome, complete genomehypothetical protein3e-33141
NC_017362:992293:996972996972997208237Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein2e-26119
NC_009092:1874888:191257119125711913092522Shewanella loihica PV-4, complete genomehypothetical protein9e-1373.6