Pre_GI Gene

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Host: NC_017355 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017355:997089 Helicobacter pylori v225d chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
997016997129114hypothetical proteinBLASTP
998712999536825hypothetical proteinBLASTP
999529999729201hypothetical protein
9999071000269363exodeoxyribonuclease 7 large subunitQuickGO ontologyBLASTP
10002751000415141hypothetical proteinBLASTP
100059910022631665hypothetical proteinBLASTP
10021871002456270hypothetical proteinBLASTP
100244910056343186hypothetical proteinBLASTP
100564110066841044hypothetical proteinBLASTP
100662410079041281TrichohyalinQuickGO ontologyBLASTP
100790110092471347hypothetical proteinBLASTP
10093961009680285hypothetical proteinBLASTP
10096771010057381hypothetical proteinBLASTP
10102101010371162hypothetical proteinBLASTP
10103641010666303hypothetical proteinBLASTP
101090410130242121hypothetical proteinBLASTP
101301810143791362protein kinase C-like proteinQuickGO ontologyBLASTP
10145401015055516serinethreonine phosphatase 2C-like proteinQuickGO ontologyBLASTP
10150521015387336hypothetical proteinBLASTP
101538410174862103FtsKSpoIIIE familyQuickGO ontologyBLASTP
10176131017867255hypothetical protein
10178771018098222hypothetical protein
10180981018433336hypothetical protein
10184201019406987hypothetical proteinBLASTP