Pre_GI: BLASTP Hits

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Query: NC_017355:997089:1010904 Helicobacter pylori v225d chromosome, complete genome

Start: 1010904, End: 1013024, Length: 2121

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017379:996500:1008689100868910113852697Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein01157
NC_017378:986611:99825099825010014803231Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein01131
NC_012973:967380:9771909771909807923603Helicobacter pylori B38 chromosome, complete genomehypothetical protein01058
NC_000915:453958:453399453399453974576Helicobacter pylori 26695, complete genomehypothetical protein2e-88327
NC_017068:1450049:1451482145148214550603579Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein5e-34146
NC_010002:4572573:4589202458920245925823381Delftia acidovorans SPH-1, complete genomeAAA ATPase5e-27123
NC_010170:4463000:4503816450381645071963381Bordetella petrii, complete genomehypothetical protein6e-27123
NC_000915:453958:453958453958454323366Helicobacter pylori 26695, complete genomehypothetical protein5e-24113
NC_012108:1694817:1696283169628316996063324Desulfobacterium autotrophicum HRM2, complete genomehypothetical protein5e-20100
NC_013410:2691437:2701566270156627047123147Fibrobacter succinogenes subsp. succinogenes S85 chromosome,Superfamily I DNA and RNA helicase and helicase subunits-like protein1e-1999
NC_008757:111292:1320491320491353753327Polaromonas naphthalenivorans CJ2 plasmid pPNAP01, completeSuperfamily I DNA and RNA helicases and helicase subunits-like protein1e-1585.9
NC_012654:237175:2407082407082438603153Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceprotein kinase domain protein4e-0860.8
NC_014933:3942156:3949999394999939519541956Bacteroides helcogenes P 36-108 chromosome, complete genomehelicase4e-0860.5
NC_008312:3923071:3938984393898439439454962Trichodesmium erythraeum IMS101, complete genomeSuperfamily I DNA and RNA helicases and helicase subunits-like2e-0758.5
NC_011000:1397611:1428615142861514334864872Burkholderia cenocepacia J2315 chromosome 1, complete sequencehypothetical protein3e-0757.8
NC_015167:2498666:2505107250510725084333327Cellulophaga lytica DSM 7489 chromosome, complete genomeserine/threonine protein kinase8e-0756.2
NC_006370:1810842:1805869180586918108454977Photobacterium profundum SS9 chromosome 1, complete sequencehypothetical protein3e-0654.3
NC_009615:1305678:1305678130567813076001923Parabacteroides distasonis ATCC 8503 chromosome, complete genomehelicase5e-0653.5