Pre_GI Gene

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Host: NC_012654 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012654:237175 Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
237175238077903efflux ABC transporter permease proteinQuickGO ontology
238046238729684methionine import ATP-binding protein MetNQuickGO ontologyBLASTP
238748239092345hypothetical protein
2393832407111329hypothetical protein
2407082438603153protein kinase domain proteinQuickGO ontologyBLASTP
244155245033879superfamily II DNA and RNA helicaseQuickGO ontologyBLASTP
2452122470921881group II intron reverse transcriptasematuraseQuickGO ontologyBLASTP
2477992517193921superfamily II DNA and RNA helicaseQuickGO ontologyBLASTP
251834252172339hypothetical protein
2522162533041089transposaseQuickGO ontologyBLASTP
253598253741144hypothetical protein
253765254133369hypothetical proteinBLASTP
254231254371141hypothetical protein
255026255223198hypothetical protein
255453255638186hypothetical protein
256011256157147hypothetical protein
256187256336150hypothetical protein
256479256904426hypothetical proteinBLASTP
256957257580624hypothetical protein
257794257958165hypothetical proteinBLASTP
2581732593721200hypothetical proteinBLASTP
259675260019345hypothetical proteinBLASTP
260085260465381death-on-curing family proteinQuickGO ontologyBLASTP
260459260629171hypothetical proteinBLASTP
260924261271348putative lipoproteinQuickGO ontology
261368261898531hypothetical proteinBLASTP
262058262372315hypothetical proteinBLASTP
262442262705264hypothetical proteinBLASTP
262833263162330hypothetical protein
263208263360153hypothetical protein
263400263594195putative CDC2L2 proteinQuickGO ontologyBLASTP
263609263827219hypothetical proteinBLASTP
263899264096198hypothetical proteinBLASTP