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Query: NC_017265:3821890:3821890 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 3821890, End: 3824175, Length: 2286

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010159:1101241:1102297110229711045822286Yersinia pestis Angola, complete genomeputative autotransporter protein01479
NC_008150:3529430:3529430352943035317152286Yersinia pestis Antiqua, complete genomeputative autotransporter protein01477
NC_005810:3238391:3254557325455732568422286Yersinia pestis biovar Microtus str. 91001, complete genomeputative autotransporter protein01477
NC_009381:427515:4436814436814459662286Yersinia pestis Pestoides F chromosome, complete genomeputative autotransporter protein01478
NC_003143:645559:6617256617256640102286Yersinia pestis CO92, complete genomeputative autotransporter protein01479
NC_004088:3955933:3956529395652939588142286Yersinia pestis KIM, complete genomehypothetical protein01479
NC_014029:699078:7152447152447175292286Yersinia pestis Z176003 chromosome, complete genomeputative autotransporter protein01479
NC_017154:640578:6573856573856596702286Yersinia pestis D106004 chromosome, complete genomeputative autotransporter protein01479
NC_017160:643406:6595726595726618572286Yersinia pestis D182038 chromosome, complete genomeputative autotransporter protein01479
NC_017168:438785:4398404398404421252286Yersinia pestis A1122 chromosome, complete genomeputative autotransporter protein01479
NC_015682:1074263:1080879108087910877246846Thermodesulfobacterium sp. OPB45 chromosome, complete genomeouter membrane autotransporter barrel domain-containing protein4e-0757.4