Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:427515 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
426875427576702hypothetical proteinBLASTP
427515428156642tellurium resistance proteinQuickGO ontologyBLASTP
428189428827639tellurium resistance proteinQuickGO ontologyBLASTP
4295424312301689hemolysin activator proteinQuickGO ontologyBLASTP
4312754411629888adhesinQuickGO ontologyBLASTP
441454441603150hypothetical proteinBLASTP
441658441885228hypothetical proteinBLASTP
442430443185756hemagglutininhemolysinQuickGO ontologyBLASTP
443249443413165hypothetical proteinBLASTP
4436814459662286putative autotransporter proteinQuickGO ontologyBLASTP
446026447021996hypothetical proteinBLASTP
4471234485021380hypothetical proteinBLASTP
4488404499431104transporter ATP-binding proteinQuickGO ontologyBLASTP
4500264533793354hypothetical proteinBLASTP