Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:438785 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
438785439780996hypothetical proteinBLASTP
4398404421252286putative autotransporter proteinQuickGO ontologyBLASTP
442393442557165hypothetical proteinBLASTP
442621443376756adhesinhemagglutininQuickGO ontologyBLASTP
443409443825417hypothetical proteinBLASTP
443921444148228hypothetical proteinBLASTP
444203444352150hypothetical proteinBLASTP
444414444647234hypothetical proteinBLASTP
4446444545319888putative adhesinQuickGO ontologyBLASTP
4545764562641689putative hemolysin activator proteinQuickGO ontologyBLASTP
456979457617639putative tellurium resistance proteinQuickGO ontologyBLASTP
457650458291642putative tellurium resistance proteinQuickGO ontologyBLASTP
458293458931639putative tellurium resistance proteinQuickGO ontologyBLASTP
459033460016984hypothetical proteinBLASTP
4600724618051734hypothetical proteinBLASTP
4618374633361500putative kinase proteinQuickGO ontologyBLASTP