Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3238391 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32377513238452702hypothetical proteinBLASTP
32383913239032642putative tellurium resistance proteinQuickGO ontologyBLASTP
32390653239703639putative tellurium resistance proteinQuickGO ontologyBLASTP
324041832421061689putative hemolysin activator proteinQuickGO ontologyBLASTP
324215132520389888putative adhesinQuickGO ontologyBLASTP
32520353252268234hypothetical proteinBLASTP
32525343252761228hypothetical proteinBLASTP
32528423253273432hypothetical proteinBLASTP
32533063254061756putative hemagglutininhemolysinQuickGO ontologyBLASTP
325455732568422286putative autotransporter proteinQuickGO ontologyBLASTP
32569023257897996hypothetical proteinBLASTP
325799932593781380hypothetical proteinBLASTP
325970132608191119putative transporter ATP-binding proteinQuickGO ontologyBLASTP