Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3955933 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39559333956469537hypothetical proteinBLASTP
395652939588142286hypothetical proteinBLASTP
39590823959246165hypothetical proteinBLASTP
39593103959930621hypothetical proteinBLASTP
39600983960529432hypothetical proteinBLASTP
39606103960837228hypothetical proteinBLASTP
39608923961041150hypothetical proteinBLASTP
396133339712209888filamentous hemagglutininQuickGO ontologyBLASTP
397126539729531689hemolysin activator proteinQuickGO ontologyBLASTP
39736683974306639hypothetical proteinBLASTP
39743393974980642tellurite resistance proteinQuickGO ontologyBLASTP
39745403974863324hypothetical protein
39749193975620702hypothetical proteinBLASTP
39757223976705984hypothetical proteinBLASTP
397676139784941734hypothetical proteinBLASTP
397852639800251500hypothetical proteinBLASTP