Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:645559 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
645559646200642putative tellurium resistance proteinQuickGO ontologyBLASTP
646233646871639putative tellurium resistance proteinQuickGO ontologyBLASTP
6475866492741689putative hemolysin activator proteinQuickGO ontologyBLASTP
6493196592069888putative adhesinQuickGO ontologyBLASTP
659203659436234hypothetical proteinBLASTP
659702659929228hypothetical proteinBLASTP
660010660441432hypothetical proteinBLASTP
6617256640102286putative autotransporter proteinQuickGO ontologyBLASTP
664070665065996hypothetical proteinBLASTP
6651676665461380hypothetical proteinBLASTP
6668696679871119putative transporter ATP-binding proteinQuickGO ontologyBLASTP