Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:643406 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
643406644047642putative tellurium resistance proteinQuickGO ontologyBLASTP
644080644718639putative tellurium resistance proteinQuickGO ontologyBLASTP
6454336471211689putative hemolysin activator proteinQuickGO ontologyBLASTP
6471666570539888putative adhesinQuickGO ontologyBLASTP
658321659076756putative hemagglutininhemolysinQuickGO ontologyBLASTP
6595726618572286putative autotransporter proteinQuickGO ontologyBLASTP
661917662912996hypothetical proteinBLASTP
6630146643931380membrane proteinQuickGO ontologyBLASTP
6647316658341104transporter ATP-binding proteinQuickGO ontologyBLASTP
6660256692703246hypothetical proteinBLASTP