Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:3529430 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
352943035317152286putative autotransporter proteinQuickGO ontologyBLASTP
35319833532147165hypothetical proteinBLASTP
35322113532966756putative hemagglutininhemolysinQuickGO ontologyBLASTP
35329993533430432hypothetical proteinBLASTP
35335113533738228hypothetical proteinBLASTP
35337933533942150hypothetical proteinBLASTP
353423435441219888putative adhesinQuickGO ontologyBLASTP
354416635458541689putative hemolysin activator proteinQuickGO ontologyBLASTP
35465693547207639putative tellurium resistance proteinQuickGO ontologyBLASTP
35472403547881642putative tellurium resistance proteinQuickGO ontologyBLASTP
35478203548521702hypothetical proteinBLASTP
35486233549606984hypothetical proteinBLASTP
354966235513951734hypothetical proteinBLASTP
355142735529261500putative kinase proteinQuickGO ontologyBLASTP