Pre_GI: OUP Neighbours

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Query: NC_008150:3529430 Yersinia pestis Antiqua, complete genome

D: 31.4433

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

Number of Neighbours: 34




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_010465:429095Yersinia pseudotuberculosis YPIII, complete genome76.6391 %Subject ←→ Query29.1646
NC_005810:4469156Yersinia pestis biovar Microtus str. 91001, complete genome77.1814 %Subject ←→ Query29.5112
NC_003143:4006884Yersinia pestis CO92, complete genome77.8186 %Subject ←→ Query29.6176
NC_008149:4053363Yersinia pestis Nepal516, complete genome77.8339 %Subject ←→ Query30.0006
NC_004088:266543Yersinia pestis KIM, complete genome77.7757 %Subject ←→ Query30.0081
NC_006155:4302826Yersinia pseudotuberculosis IP 32953, complete genome77.6716 %Subject ←→ Query30.1556
NC_003143:2778494Yersinia pestis CO92, complete genome80.098 %Subject ←→ Query30.2293
NC_010634:4234932Yersinia pseudotuberculosis PB1/+, complete genome78.4436 %Subject ←→ Query30.3016
NC_008149:1221637Yersinia pestis Nepal516, complete genome75.4228 %Subject ←→ Query30.5812
NC_015663:1902344*Enterobacter aerogenes KCTC 2190 chromosome, complete genome76.8474 %Subject ←→ Query31.1284
NC_012962:3864000*Photorhabdus asymbiotica, complete genome75.8333 %Subject ←→ Query31.492
NC_014306:2476316Erwinia billingiae Eb661, complete genome78.9216 %Subject ←→ Query32.9311
NC_010634:1565788Yersinia pseudotuberculosis PB1/+, complete genome76.2316 %Subject ←→ Query33.0113
NC_006155:1567306Yersinia pseudotuberculosis IP 32953, complete genome76.1642 %Subject ←→ Query33.2342
NC_004088:3955933Yersinia pestis KIM, complete genome95.8609 %Subject ←→ Query33.4603
NC_010159:1101241Yersinia pestis Angola, complete genome95.3431 %Subject ←→ Query33.9894
NC_010634:4045794Yersinia pseudotuberculosis PB1/+, complete genome88.1036 %Subject ←→ Query34.0011
NC_005810:3238391Yersinia pestis biovar Microtus str. 91001, complete genome91.682 %Subject ←→ Query34.2139
NC_014562:1883517*Pantoea vagans C9-1 chromosome, complete genome77.4969 %Subject ←→ Query34.2182
NC_006155:4105542Yersinia pseudotuberculosis IP 32953, complete genome88.1618 %Subject ←→ Query34.268
NC_003143:645559Yersinia pestis CO92, complete genome91.7402 %Subject ←→ Query34.4007
NC_013421:2720500Pectobacterium wasabiae WPP163, complete genome77.4847 %Subject ←→ Query34.6251
NC_014562:1402863Pantoea vagans C9-1 chromosome, complete genome75.0643 %Subject ←→ Query35.29
NC_012779:2424967*Edwardsiella ictaluri 93-146, complete genome75.8088 %Subject ←→ Query35.992
NC_010694:2189652*Erwinia tasmaniensis, complete genome76.1642 %Subject ←→ Query37.4179
NC_005126:1265071Photorhabdus luminescens subsp. laumondii TTO1, complete genome75.4228 %Subject ←→ Query37.9976
NC_012779:3176820*Edwardsiella ictaluri 93-146, complete genome77.9596 %Subject ←→ Query39.7546
NC_012779:2281700*Edwardsiella ictaluri 93-146, complete genome77.1048 %Subject ←→ Query40.1776
NC_014228:3282500Xenorhabdus nematophila ATCC 19061, complete genome75.2451 %Subject Query41.4806
NC_012779:2928000*Edwardsiella ictaluri 93-146, complete genome77.4939 %Subject Query41.5453
NC_012779:1449500*Edwardsiella ictaluri 93-146, complete genome76.7402 %Subject Query41.6091
NC_013508:876431*Edwardsiella tarda EIB202, complete genome78.2966 %Subject Query41.7282
NC_015566:4662171Serratia sp. AS12 chromosome, complete genome77.4908 %Subject Query41.8855
NC_013283:113660Cronobacter turicensis plasmid pCTU1, complete sequence76.8597 %Subject Query42.151