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Query: NC_014560:1366747:1396700 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1396700, End: 1396864, Length: 165

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017372:748097:767240767240767404165Helicobacter pylori India7 chromosome, complete genomehypothetical protein9e-24108
NC_017371:1470582:148937714893771489541165Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein9e-24108
NC_017063:834674:869384869384869548165Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein9e-24108
NC_014256:485969:504844504844505008165Helicobacter pylori B8 chromosome, complete genomehypothetical protein9e-24108
NC_017362:1512959:153520215352021535366165Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein2e-23107
NC_017375:77142:891488914889312165Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-1478.6
NC_017366:1055319:107304410730441073208165Helicobacter pylori F32, complete genomehypothetical protein2e-1477.8
NC_017378:1518529:153839715383971538567171Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein2e-1063.9