Pre_GI Gene

Some Help

Host: NC_017371 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017371:1470582 Helicobacter pylori Gambia94/24 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
146852014705982079hypothetical proteinBLASTP
14705821471571990arabinose-5-phosphate isomeraseQuickGO ontologyBLASTP
147156814726411074ribosomal RNA large subunit methyltransferase NQuickGO ontologyBLASTP
1472794147288693hypothetical proteinBLASTP
1473112147320493hypothetical proteinBLASTP
14732861473843558type I R-M system specificity subunitQuickGO ontologyBLASTP
147466614766962031relaxaseQuickGO ontologyBLASTP
147784814789181071integraserecombinase xerDQuickGO ontologyBLASTP
14792261480029804hypothetical proteinBLASTP
14800011480252252hypothetical proteinBLASTP
14803841481064681hypothetical proteinBLASTP
148128514822981014hypothetical proteinBLASTP
148230314835801278hypothetical proteinBLASTP
148357714848391263type IV secretion system protein TrbLQuickGO ontologyBLASTP
148483614862691434hypothetical proteinBLASTP
148627914883242046hypothetical proteinBLASTP
148832414893761053hypothetical proteinBLASTP
14893771489541165hypothetical proteinBLASTP
14901781490846669hypothetical proteinBLASTP
14908931491270378hypothetical proteinBLASTP
14912481491913666hypothetical proteinBLASTP
14919871492790804hypothetical proteinBLASTP
14927601493230471hypothetical proteinBLASTP
149328514953452061DNA topoisomerase IQuickGO ontologyBLASTP
14953581495759402hypothetical proteinBLASTP
14960591496268210hypothetical proteinBLASTP
14962791496392114hypothetical proteinBLASTP
150534015072441905VirD4 coupling proteinQuickGO ontologyBLASTP
15072411507759519hypothetical proteinBLASTP
15077561508700945VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
15087051508899195hypothetical proteinBLASTP
15089931509955963hypothetical proteinBLASTP
150996815122082241hypothetical proteinBLASTP
151219215134001209VirB10 type IV secretion proteinQuickGO ontologyBLASTP
151339715150521656type IV secretion system protein VirB9QuickGO ontologyBLASTP
151504915161851137VirB8 type IV secretion proteinQuickGO ontologyBLASTP
15161781516318141VirB7 type IV secretion proteinQuickGO ontologyBLASTP
151631515188912577VirB4 type IV secretion ATPaseQuickGO ontologyBLASTP
15188911519127237hypothetical proteinBLASTP