Pre_GI Gene

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Host: NC_017378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017378:1518529 Helicobacter pylori Puno120 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
151852915196801152restriction modification system DNA specificity subunitQuickGO ontologyBLASTP
15196771520444768hypothetical protein
152305015241261077typeI restriction enzyme R proteinQuickGO ontologyBLASTP
15247691525569801hypothetical proteinBLASTP
152627815321095832hypothetical proteinBLASTP
1532106153220499hypothetical protein
15322721532490219hypothetical proteinBLASTP
153248015345432064topoisomerase IQuickGO ontologyBLASTP
15345981535068471hypothetical proteinBLASTP
15350381535829792hypothetical proteinBLASTP
15359311536569639hypothetical proteinBLASTP
15365471536939393hypothetical proteinBLASTP
15369801537648669hypothetical proteinBLASTP
15383971538567171hypothetical proteinBLASTP
153856415396281065hypothetical proteinBLASTP
153962815411481521hypothetical proteinBLASTP
154115915425921434hypothetical proteinBLASTP
154258915438541266hypothetical proteinBLASTP
154385115451371287hypothetical proteinBLASTP