Pre_GI Gene

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Host: NC_017366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017366:1055319 Helicobacter pylori F32, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
105531910569441626arginyl-tRNA synthetaseQuickGO ontologyBLASTP
10570051057760756hypothetical proteinBLASTP
10582361059024789integraserecombinase XERCD familyQuickGO ontologyBLASTP
10591281059607480hypothetical proteinBLASTP
10596041059888285hypothetical proteinBLASTP
10598991060162264hypothetical proteinBLASTP
10601731060409237hypothetical proteinBLASTP
106040910615571149virB4 proteinQuickGO ontologyBLASTP
106164610626621017virB4 type IV secretion ATPaseQuickGO ontologyBLASTP
106261910661703552hypothetical proteinBLASTP
10661671066292126hypothetical proteinBLASTP
10663061066560255hypothetical protein
10667811066903123hypothetical protein
106730510693682064topoisomerase IQuickGO ontologyBLASTP
10694231069893471hypothetical proteinBLASTP
10698631070663801hypothetical proteinBLASTP
10707861071358573hypothetical proteinBLASTP
10713361071695360hypothetical proteinBLASTP
10717571072407651PARA proteinQuickGO ontologyBLASTP
10730441073208165hypothetical proteinBLASTP
107320910742761068hypothetical proteinBLASTP
107427610756401365hypothetical proteinBLASTP