Pre_GI Gene

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Host: NC_017372 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017372:748097 Helicobacter pylori India7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7480977499651869adenine specific DNA methyltransferaseQuickGO ontologyBLASTP
7499627520042043putative type III restriction enzyme R protein ResQuickGO ontologyBLASTP
752596752706111hypothetical protein
7529897550192031hypothetical proteinBLASTP
7561247571911068integraserecombinase xerDQuickGO ontologyBLASTP
757510758334825hypothetical proteinBLASTP
758306758557252hypothetical proteinBLASTP
759698760345648hypothetical proteinBLASTP
7603497616051257hypothetical proteinBLASTP
7616027628371236hypothetical proteinBLASTP
7628377642701434hypothetical proteinBLASTP
7642807661871908hypothetical proteinBLASTP
7661877672391053hypothetical proteinBLASTP
767240767404165hypothetical proteinBLASTP
768038768688651hypothetical proteinBLASTP
768750769127378hypothetical proteinBLASTP
769114769677564hypothetical proteinBLASTP
769812770591780hypothetical proteinBLASTP
770561771031471hypothetical proteinBLASTP
7710867731492064topoisomerase IQuickGO ontologyBLASTP
77316277325796hypothetical protein
7732547818548601adenine specific DNA methyltransferaseQuickGO ontologyBLASTP
7818747841262253VirD4 coupling proteinQuickGO ontologyBLASTP
784123784641519hypothetical proteinBLASTP
784638785582945VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
785587785859273hypothetical proteinBLASTP
785877786854978hypothetical proteinBLASTP
7868677891282262hypothetical proteinBLASTP
7891127903141203type IV secretion system protein VirB10QuickGO ontologyBLASTP
7903117919061596type IV secretion system protein VirB9QuickGO ontologyBLASTP
7919037930721170VirB8 type IV secretion proteinQuickGO ontologyBLASTP
793065793199135hypothetical protein
7931967957782583VirB4 type IV secretion ATPaseQuickGO ontologyBLASTP
795778796014237hypothetical proteinBLASTP