Pre_GI Gene

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Host: NC_017362 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017362:1512959 Helicobacter pylori Lithuania75 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
151295915147521794glucosamine--fructose-6-phosphate aminotransferaseQuickGO ontologyBLASTP
15147751515401627FAD-dependent thymidylate synthaseQuickGO ontologyBLASTP
1515521151561393hypothetical proteinBLASTP
1515836151592893hypothetical protein
15160291516139111type I R-M system S proteinQuickGO ontologyBLASTP
15161751516576402putative type I restriction enzyme specificity proteinQuickGO ontologyBLASTP
151746715195002034relaxaseQuickGO ontologyBLASTP
152065515217221068integraserecombinase xerDQuickGO ontologyBLASTP
15220391522842804hypothetical proteinBLASTP
15228141523065252hypothetical proteinBLASTP
1523849152394193hypothetical protein
152555815268201263type IV secretion system protein TrbLQuickGO ontologyBLASTP
15301361530453318hypothetical proteinBLASTP
15307821530970189hypothetical protein
15309841531745762hypothetical proteinBLASTP
15317321532610879hypothetical proteinBLASTP
15326271533508882hypothetical proteinBLASTP
15335631533889327hypothetical proteinBLASTP
15338931534204312hypothetical proteinBLASTP
15352021535366165hypothetical proteinBLASTP
15360031536671669hypothetical proteinBLASTP
15367181537095378hypothetical proteinBLASTP
15370731537720648hypothetical proteinBLASTP
15378601538588729hypothetical proteinBLASTP
15385851539055471hypothetical proteinBLASTP
153911015411702061DNA topoisomerase IQuickGO ontologyBLASTP
15411831541584402hypothetical proteinBLASTP
15416351541886252hypothetical proteinBLASTP
15419661542091126hypothetical proteinBLASTP
154221215508128601adenine specific DNA methyltransferaseQuickGO ontologyBLASTP