Pre_GI Gene

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Host: NC_017063 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017063:834674 Helicobacter pylori ELS37 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8346748359511278plasminogen binding proteinQuickGO ontology
835992836630639UDP-sugar diphosphataseQuickGO ontologyBLASTP
8366308378411212putative outer membrane proteinQuickGO ontologyBLASTP
838051838308258hypothetical protein
838627839415789hypothetical proteinBLASTP
839418839630213hypothetical proteinBLASTP
839640840128489hypothetical proteinBLASTP
840116840400285hypothetical proteinBLASTP
840412840675264hypothetical proteinBLASTP
840687840923237hypothetical proteinBLASTP
843497843637141VirB7 type IV secretion proteinQuickGO ontologyBLASTP
843630844016387putative VirB8 proteinQuickGO ontologyBLASTP
8441078455611455type IV secretion system protein VirB9QuickGO ontologyBLASTP
8455588467661209VirB10 type IV secretion proteinQuickGO ontologyBLASTP
849002849973972hypothetical proteinBLASTP
849991850266276hypothetical proteinBLASTP
850268851215948VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
851212851730519hypothetical proteinBLASTP
8517278539702244VirD4 coupling proteinQuickGO ontologyBLASTP
8539908625368547adenine specific DNA methyltransferaseQuickGO ontologyBLASTP
862657862866210hypothetical proteinBLASTP
862863863114252hypothetical proteinBLASTP
863183863566384hypothetical proteinBLASTP
8635798656392061topoisomerase IQuickGO ontologyBLASTP
865694866164471hypothetical proteinBLASTP
866134866937804hypothetical proteinBLASTP
867011867676666hypothetical proteinBLASTP
867654868031378hypothetical proteinBLASTP
868078868746669hypothetical proteinBLASTP
869384869548165hypothetical proteinBLASTP
8695498706011053hypothetical proteinBLASTP
8706018723101710hypothetical proteinBLASTP
8723208737531434hypothetical proteinBLASTP
8737508750121263type IV secretion system protein TrbLQuickGO ontologyBLASTP
8750098762861278hypothetical proteinBLASTP
877527877967441hypothetical proteinBLASTP
878330878581252hypothetical proteinBLASTP
878553879356804hypothetical proteinBLASTP
8796738807401068integraserecombinase xerDQuickGO ontologyBLASTP
881240881368129hypothetical proteinBLASTP