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Query: NC_004088:3505383:3520008 Yersinia pestis KIM, complete genome

Start: 3520008, End: 3520598, Length: 591

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008149:3373229:338784633878463388436591Yersinia pestis Nepal516, complete genomegeneral secretion pathway protein H1e-111401
NC_005810:3142384:315883331588333159423591Yersinia pestis biovar Microtus str. 91001, complete genomegeneral secretory pathway proteins G and H and related periplasmic/secreted proteins1e-111401
NC_009381:775357:790675790675791265591Yersinia pestis Pestoides F chromosome, complete genomegeneral secretion pathway protein H4e-111400
NC_003143:875367:889984889984890526543Yersinia pestis CO92, complete genomegeneral secretion pathway protein H3e-102370
NC_008150:513783:530274530274530816543Yersinia pestis Antiqua, complete genomehypothetical protein3e-102370
NC_017168:199381:214748214748215290543Yersinia pestis A1122 chromosome, complete genomegeneral secretion pathway protein H3e-102370
NC_017265:1000342:101683610168361017378543Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,general secretion pathway protein H3e-102370
NC_010634:3509880:352450935245093525051543Yersinia pseudotuberculosis PB1/+, complete genomegeneral secretion pathway protein H9e-102369
NC_006155:3596120:361074936107493611291543Yersinia pseudotuberculosis IP 32953, complete genomegeneral secretion pathway protein H9e-102369
NC_010465:1118147:113534711353471135889543Yersinia pseudotuberculosis YPIII, complete genomegeneral secretion pathway protein H9e-102369