Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:875367 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8743488753701023galactose operon repressorQuickGO ontologyBLASTP
8753678766291263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
876844877785942transcriptional activator protein LysRQuickGO ontologyBLASTP
8777828789421161putative sugar transport proteinQuickGO ontologyBLASTP
879311880219909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
880326881213888hypothetical proteinBLASTP
881326881961636hypothetical proteinBLASTP
8819478835901644putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
883793884194402hypothetical proteinBLASTP
884191884907717putative regulatory membrane proteinQuickGO ontologyBLASTP
885191885496306putative lipoproteinQuickGO ontologyBLASTP
885548886390843prepilin peptidaseQuickGO ontologyBLASTP
886416886877462hypothetical proteinBLASTP
8868748880431170general secretion pathway protein LQuickGO ontologyBLASTP
888048889004957general secretion pathway protein KQuickGO ontologyBLASTP
889013889609597general secretion pathway protein JQuickGO ontologyBLASTP
889602889946345general secretion pathway protein IQuickGO ontologyBLASTP
889984890526543general secretion pathway protein HQuickGO ontologyBLASTP
890531890968438general secretion pathway protein GQuickGO ontologyBLASTP
8921768936871512general secretion pathway protein EQuickGO ontologyBLASTP
8936848956061923general secretion pathway protein DQuickGO ontologyBLASTP
895687896190504general secretion pathway protein CQuickGO ontologyBLASTP
896258896674417hypothetical proteinBLASTP
897417898172756putative carbonic anhydraseQuickGO ontologyBLASTP
898548898856309hypothetical proteinBLASTP
899243899437195hypothetical proteinBLASTP
899459900409951hypothetical proteinBLASTP
9005249027102187hypothetical proteinBLASTP
9027809058933114hypothetical proteinBLASTP
906238907020783transposaseIS proteinQuickGO ontologyBLASTP
9070179080391023transposase for insertion sequence IS100QuickGO ontologyBLASTP
9089829105351554putative sulfataseQuickGO ontologyBLASTP