Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:513783 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
513783514562780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
514613514738126transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
5149075180203114hypothetical proteinBLASTP
5180905202762187hypothetical proteinBLASTP
520391521341951hypothetical proteinBLASTP
521363521557195hypothetical proteinBLASTP
521944522252309hypothetical proteinBLASTP
522628523383756putative carbonic anhydraseQuickGO ontologyBLASTP
524126524542417hypothetical proteinBLASTP
524580525113534general secretion pathway protein CQuickGO ontologyBLASTP
5251945271161923general secretion pathway protein DQuickGO ontologyBLASTP
5272635286241362general secretion pathway protein EQuickGO ontologyBLASTP
5287665298121047putative general protein secretion proteinQuickGO ontologyBLASTP
529832530269438general secretion pathway protein GQuickGO ontologyBLASTP
530274530816543hypothetical proteinBLASTP
530854531198345general secretion pathway protein IQuickGO ontologyBLASTP
531170531787618general secretion pathway protein JQuickGO ontologyBLASTP
531796532752957general secretion pathway protein KQuickGO ontologyBLASTP
5327365339261191general secretion pathway protein LQuickGO ontologyBLASTP
533923534384462hypothetical proteinBLASTP
534410535252843prepilin peptidaseQuickGO ontologyBLASTP
535304535609306putative lipoproteinQuickGO ontologyBLASTP
535893536642750putative regulatory membrane proteinQuickGO ontologyBLASTP
536605537006402hypothetical proteinBLASTP
5371615388521692putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
538838539473636hypothetical proteinBLASTP
539586540473888hypothetical proteinBLASTP
540580541488909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
5418575430171161putative sugar transport proteinQuickGO ontologyBLASTP
543014543955942transcriptional activator protein LysRQuickGO ontologyBLASTP
5441705454321263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
5454295464511023galactose operon repressorQuickGO ontologyBLASTP
5467615490222262putative biotin sulfoxide reductas2QuickGO ontologyBLASTP