Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3142384 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
314136531423871023transposase for insertion sequence IS100QuickGO ontologyBLASTP
31423843143166783transposaseIS proteinQuickGO ontologyBLASTP
314351131466243114hypothetical proteinBLASTP
314669431488952202hypothetical proteinBLASTP
31489953149945951hypothetical proteinBLASTP
31499673150161195hypothetical proteinBLASTP
31505503150858309hypothetical proteinBLASTP
31512343151989756putative carbonic anhydraseQuickGO ontologyBLASTP
31527323153148417hypothetical proteinBLASTP
31531863153719534general secretion pathway protein CQuickGO ontologyBLASTP
315380031557221923general secretion pathway protein DQuickGO ontologyBLASTP
315571931572301512general secretion pathway protein EQuickGO ontologyBLASTP
315721131584191209putative general protein secretion proteinQuickGO ontologyBLASTP
31584393158876438general secretion pathway protein GQuickGO ontologyBLASTP
31588333159423591general secretory pathway proteins G and H and related periplasmicsecreted proteinsQuickGO ontologyBLASTP
31594613159805345general secretion pathway protein IQuickGO ontologyBLASTP
31597773160394618general secretion pathway protein JQuickGO ontologyBLASTP
31604033161359957general secretion pathway protein KQuickGO ontologyBLASTP
316134331625331191general secretion pathway protein LQuickGO ontologyBLASTP
31625303162991462hypothetical proteinBLASTP
31629453163859915prepilin peptidaseQuickGO ontologyBLASTP
31638433164208366putative lipoproteinQuickGO ontologyBLASTP
316495531661631209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
31665283166929402hypothetical proteinBLASTP
316707531687751701methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
31687613169396636hypothetical proteinBLASTP
31695093170396888hypothetical proteinBLASTP
31705033171411909LysR family transcriptional regulatorQuickGO ontologyBLASTP
317178031729401161putative sugar transport proteinQuickGO ontologyBLASTP
31729373173878942DNA-binding transcriptional regulator LysRQuickGO ontologyBLASTP
317409331753551263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
317535231765361185DNA-binding transcriptional regulator GalRQuickGO ontologyBLASTP
317668431789452262putative biotin sulfoxide reductas2QuickGO ontologyBLASTP