Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3373229 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
337221033732321023galactose operon repressorQuickGO ontologyBLASTP
337322933744911263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
33747063375647942transcriptional activator protein LysRQuickGO ontologyBLASTP
337564433768041161sugar transport proteinQuickGO ontologyBLASTP
33771733378081909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
33781883379075888hypothetical proteinBLASTP
33791883379823636hypothetical proteinBLASTP
337980933815001692methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
33816553382056402hypothetical proteinBLASTP
33820533382769717regulatory membrane proteinQuickGO ontologyBLASTP
33830533383358306lipoproteinQuickGO ontologyBLASTP
33834103384252843prepilin peptidaseQuickGO ontologyBLASTP
33842783384739462membrane proteinQuickGO ontologyBLASTP
338473633859261191general secretion pathway protein LQuickGO ontologyBLASTP
33859103386866957general secretion pathway protein KQuickGO ontologyBLASTP
33868753387492618general secretion pathway protein JQuickGO ontologyBLASTP
33874643387808345general secretion pathway protein IQuickGO ontologyBLASTP
33878463388436591general secretion pathway protein HQuickGO ontologyBLASTP
33883933388830438general secretion pathway protein GQuickGO ontologyBLASTP
338885033898961047general protein secretion proteinQuickGO ontologyBLASTP
339003833913991362general secretion pathway protein EQuickGO ontologyBLASTP
339154633934681923general secretion pathway protein DQuickGO ontologyBLASTP
33935493394082534general secretion pathway protein CQuickGO ontologyBLASTP
33941203394536417hypothetical proteinBLASTP
33952793396034756carbonic anhydraseQuickGO ontologyBLASTP
33964103396718309hypothetical proteinBLASTP
33973213398271951hypothetical proteinBLASTP
339838634005722187hypothetical proteinBLASTP
340064234037553114hypothetical proteinBLASTP
34039243404049126transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
34041003404879780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
340487934059011023transposase for insertion sequence IS100QuickGO ontologyBLASTP
34059583406392435transposaseQuickGO ontologyBLASTP
340684434083971554sulfataseQuickGO ontologyBLASTP