Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:199381 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1993812024943114hypothetical proteinBLASTP
2025642047502187hypothetical proteinBLASTP
204865205815951hypothetical proteinBLASTP
206418206726309hypothetical proteinBLASTP
207102207857756carbonic anhydraseQuickGO ontologyBLASTP
208600209016417hypothetical proteinBLASTP
209054209587534general secretion pathway protein CQuickGO ontologyBLASTP
2096682115901923general secretion pathway protein DQuickGO ontologyBLASTP
2115872130981512general secretion pathway protein EQuickGO ontologyBLASTP
213085213279195general secretion pathway protein FQuickGO ontologyBLASTP
213315214286972putative general protein secretion proteinQuickGO ontologyBLASTP
214306214743438general secretion pathway protein GQuickGO ontologyBLASTP
214748215290543general secretion pathway protein HQuickGO ontologyBLASTP
215328215672345general secretion pathway protein IQuickGO ontologyBLASTP
215665216261597general secretion pathway protein JQuickGO ontologyBLASTP
216270217226957general secretion pathway protein KQuickGO ontologyBLASTP
2172102184001191general secretion pathway protein LQuickGO ontologyBLASTP
218397218858462hypothetical proteinBLASTP
218884219726843prepilin peptidaseQuickGO ontologyBLASTP
219771220091321hypothetical proteinBLASTP
220375221091717putative regulatory membrane proteinQuickGO ontologyBLASTP
221088221489402hypothetical proteinBLASTP
2216442233351692methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
223321223956636putative protein-disulfide isomeraseQuickGO ontologyBLASTP
224069224956888hypothetical proteinBLASTP
225063225971909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
2263402275001161putative sugar transport proteinQuickGO ontologyBLASTP
227497228438942DNA-binding transcriptional regulator LysRQuickGO ontologyBLASTP
2286532299151263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
2299122309341023DNA-binding transcriptional regulator GalRQuickGO ontologyBLASTP
2312442335052262putative biotin sulfoxide reductas2QuickGO ontologyBLASTP