Query: NC_012943:3299744 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome
Start: 3299744, End: 3321636, Length: 21893
Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Start | End | Length | Subject Host Description | E-value | Bit score | Visual BLASTN | Visual BLASTP |
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NC_009565:1098847* | 1098847 | 1120293 | 21447 | Mycobacterium tuberculosis F11, complete genome | 0 | 31950 | BLASTN svg | BLASTP svg |
NC_009525:1096386* | 1096386 | 1118456 | 22071 | Mycobacterium tuberculosis H37Ra, complete genome | 0 | 31860 | BLASTN svg | BLASTP svg |
NC_000962:1095078* | 1095078 | 1115749 | 20672 | Mycobacterium tuberculosis H37Rv, complete genome | 0 | 31860 | BLASTN svg | BLASTP svg |
NC_002945:1095337* | 1095337 | 1117599 | 22263 | Mycobacterium bovis AF2122/97, complete genome | 0 | 31800 | BLASTN svg | BLASTP svg |
NC_012207:1097228* | 1097228 | 1117899 | 20672 | Mycobacterium bovis BCG str. Tokyo 172, complete genome | 0 | 31800 | BLASTN svg | BLASTP svg |
NC_008769:1125567* | 1125567 | 1147637 | 22071 | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome | 0 | 31800 | BLASTN svg | BLASTP svg |
NC_002755:1095105* | 1095105 | 1115787 | 20683 | Mycobacterium tuberculosis CDC1551, complete genome | 0 | 31690 | BLASTN svg | BLASTP svg |
NC_015848:1105892* | 1105892 | 1127326 | 21435 | Mycobacterium canettii CIPT 140010059, complete genome | 0 | 31490 | BLASTN svg | BLASTP svg |
NC_010397:1099312* | 1099312 | 1122647 | 23336 | Mycobacterium abscessus chromosome Chromosome, complete sequence | 9e-37 | 163 | BLASTN svg | BLASTP svg |
NC_006361:5146000* | 5146000 | 5173599 | 27600 | Nocardia farcinica IFM 10152, complete genome | 4e-36 | 161 | BLASTN svg | BLASTP svg |
NC_013159:3554389* | 3554389 | 3573622 | 19234 | Saccharomonospora viridis DSM 43017, complete genome | 9e-31 | 143 | BLASTN svg | BLASTP svg |
NC_007777:75885 | 75885 | 98099 | 22215 | Frankia sp. CcI3, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_010612:5403000 | 5403000 | 5421412 | 18413 | Mycobacterium marinum M, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_015312:848403* | 848403 | 867717 | 19315 | Pseudonocardia dioxanivorans CB1190 chromosome, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_020133:5020500 | 5020500 | 5042741 | 22242 | Mycobacterium liflandii 128FXT, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_015138:1143015 | 1143015 | 1165430 | 22416 | Acidovorax avenae subsp. avenae ATCC 19860 chromosome, complete | 2e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_020302:2219378 | 2219378 | 2246099 | 26722 | Corynebacterium halotolerans YIM 70093 = DSM 44683, complete | 7e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_008268:5781604* | 5781604 | 5814244 | 32641 | Rhodococcus sp. RHA1, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_010612:6113155 | 6113155 | 6132654 | 19500 | Mycobacterium marinum M, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_011992:773905 | 773905 | 797509 | 23605 | Acidovorax ebreus TPSY, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_020133:5710661 | 5710661 | 5732244 | 21584 | Mycobacterium liflandii 128FXT, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_008278:81866* | 81866 | 102166 | 20301 | Frankia alni ACN14a, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_008148:3024867 | 3024867 | 3046715 | 21849 | Rubrobacter xylanophilus DSM 9941, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_015677:3339181* | 3339181 | 3363881 | 24701 | Ramlibacter tataouinensis TTB310 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_014323:4619344* | 4619344 | 4652417 | 33074 | Herbaspirillum seropedicae SmR1 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_014318:7821227* | 7821227 | 7859599 | 38373 | Amycolatopsis mediterranei U32 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |