Pre_GI Gene

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Host: NC_000962 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000962:1095078 Mycobacterium tuberculosis H37Rv, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109507810964511374PE-PGRS FAMILY PROTEINQuickGO ontologyBLASTP
10968161097508693MYCOBACTERIAL PERSISTENCE REGULATOR MRPA TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEINQuickGO ontologyBLASTP
109750810990221515PROBABLE TWO COMPONENT SENSOR KINASE MPRBQuickGO ontologyBLASTP
109906611004601395PROBABLE SERINE PROTEASE PEPD SERINE PROTEINASE MTB32BQuickGO ontologyBLASTP
11004601101005546POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB2 PHS 4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE PTERIN-4-A-CARBINOLAMINE DEHYDRATASE PQuickGO ontologyBLASTP
11010251101480456large-conductance mechanosensitive channelQuickGO ontologyBLASTP
11018031102549747PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTERQuickGO ontologyBLASTP
110254211051092568PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTERQuickGO ontologyBLASTP
110511611062761161POSSIBLE CONSERVED EXPORTED PROTEINQuickGO ontologyBLASTP
11064051107382978PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 POLYPRENYL PYROPHOSPHATE SYNTHETASEQuickGO ontologyBLASTP
11074431108099657hypothetical proteinBLASTP
11081721108504333CONSERVED HYPOTHETICAL SERINE RICH PROTEINQuickGO ontologyBLASTP
11085781109171594hypothetical proteinBLASTP
11092721110192921PROBABLE UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE GALU UDP-GLUCOSE PYROPHOSPHORYLASE UDPGP ALPHA-D-GLUCOSYL-1-PHOSPHATE URIDYLYLTRANSFERASE QuickGO ontologyBLASTP
111026911115491281PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA1QuickGO ontologyBLASTP
11116121112223612POSSIBLE RIBOSOMAL-PROTEIN-ALANINE ACETYLTRANSFERASE RIMJ ACETYLATING ENZYME FOR N-TERMINAL OF RIBOSOMAL PROTEIN S5QuickGO ontologyBLASTP
111238411134601077PROBABLE CONSERVED TRANSMEMBRANE PROTEINQuickGO ontologyBLASTP
11142931114724432hypothetical proteinBLASTP
111474811157491002hypothetical proteinBLASTP