Pre_GI Gene

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Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:1105892 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11076231108315693persistence regulator MRPAQuickGO ontologyBLASTP
110831511098291515putative two component sensor kinase MPRBQuickGO ontologyBLASTP
110987311112671395putative serine proteaseQuickGO ontologyBLASTP
11112671111812546putative pterin-4-alpha-carbinolamine dehydratase MOAB2QuickGO ontologyBLASTP
11118321112287456putative large-conductance ion mechanosensitive channel MSCLQuickGO ontologyBLASTP
11126101113356747putative adhesion component transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
111334911159162568putative adhesion component transport transmembrane protein ABC transporterQuickGO ontologyBLASTP
111592311170831161hypothetical proteinBLASTP
11172121118189978putative polyprenyl-diphosphate synthase GRCC2QuickGO ontologyBLASTP
11182501118906657hypothetical proteinBLASTP
11189791119311333hypothetical proteinBLASTP
11193851119978594hypothetical proteinBLASTP
11200791120999921putative UTP--glucose-1-phosphate uridylyltransferase GALUQuickGO ontologyBLASTP
112107611223561281putative molybdopterin biosynthesis protein MOEA1QuickGO ontologyBLASTP
11224191123030612putative ribosomal-protein-alanine acetyltransferase RIMJQuickGO ontologyBLASTP
112319111242611071hypothetical proteinBLASTP
11250941125525432hypothetical proteinBLASTP
112554911265501002hypothetical proteinBLASTP
11265681127326759hypothetical proteinBLASTP