Pre_GI Gene

Some Help

Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:1096386 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109638610977591374PE-PGRS family proteinQuickGO ontologyBLASTP
10981241098816693mycobacterial persistence regulator MrpAQuickGO ontologyBLASTP
109881611003301515putative two component sensor kinase MprBQuickGO ontologyBLASTP
110037411017681395serine protease PepDQuickGO ontologyBLASTP
11017681102313546pterin-4-alpha-carbinolamine dehydratase MoaB2QuickGO ontologyBLASTP
11023331102788456large-conductance mechanosensitive channelQuickGO ontologyBLASTP
11031111103857747adhesion component ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
110385011064172568adhesion component ABC transporter permease proteinQuickGO ontologyBLASTP
110642411075841161putative conserved exported proteinQuickGO ontologyBLASTP
11077131108690978polyprenyl-diphosphate synthase GrcC2QuickGO ontologyBLASTP
11087511109407657hypothetical proteinBLASTP
11094801109812333conserved hypothetical serine rich proteinQuickGO ontologyBLASTP
11098861110479594hypothetical proteinBLASTP
11105801111500921UTP--glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
111157711128571281molybdopterin biosynthesis protein MoeA1QuickGO ontologyBLASTP
11129201113531612ribosomal-protein-alanine acetyltransferase RimJQuickGO ontologyBLASTP
111369211147681077putative conserved transmembrane proteinQuickGO ontologyBLASTP
11151691115420252hypothetical proteinBLASTP
11156011116032432hypothetical proteinBLASTP
111605611170571002hypothetical proteinBLASTP
11170751117833759hypothetical proteinBLASTP
11178391118456618hypothetical proteinBLASTP