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Query: NC_012943:3299744 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3299744, End: 3321636, Length: 21893

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009565:1098847*1098847112029321447Mycobacterium tuberculosis F11, complete genome031950BLASTN svgBLASTP svg
NC_009525:1096386*1096386111845622071Mycobacterium tuberculosis H37Ra, complete genome031860BLASTN svgBLASTP svg
NC_000962:1095078*1095078111574920672Mycobacterium tuberculosis H37Rv, complete genome031860BLASTN svgBLASTP svg
NC_002945:1095337*1095337111759922263Mycobacterium bovis AF2122/97, complete genome031800BLASTN svgBLASTP svg
NC_012207:1097228*1097228111789920672Mycobacterium bovis BCG str. Tokyo 172, complete genome031800BLASTN svgBLASTP svg
NC_008769:1125567*1125567114763722071Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome031800BLASTN svgBLASTP svg
NC_002755:1095105*1095105111578720683Mycobacterium tuberculosis CDC1551, complete genome031690BLASTN svgBLASTP svg
NC_015848:1105892*1105892112732621435Mycobacterium canettii CIPT 140010059, complete genome031490BLASTN svgBLASTP svg
NC_010397:1099312*1099312112264723336Mycobacterium abscessus chromosome Chromosome, complete sequence9e-37163BLASTN svgBLASTP svg
NC_006361:5146000*5146000517359927600Nocardia farcinica IFM 10152, complete genome4e-36161BLASTN svgBLASTP svg
NC_013159:3554389*3554389357362219234Saccharomonospora viridis DSM 43017, complete genome9e-31143BLASTN svgBLASTP svg
NC_007777:75885758859809922215Frankia sp. CcI3, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_010612:54030005403000542141218413Mycobacterium marinum M, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_015312:848403*84840386771719315Pseudonocardia dioxanivorans CB1190 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_020133:50205005020500504274122242Mycobacterium liflandii 128FXT, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_015138:11430151143015116543022416Acidovorax avenae subsp. avenae ATCC 19860 chromosome, complete2e-1075.8BLASTN svgBLASTP svg
NC_020302:22193782219378224609926722Corynebacterium halotolerans YIM 70093 = DSM 44683, complete7e-1073.8BLASTN svgBLASTP svg
NC_008268:5781604*5781604581424432641Rhodococcus sp. RHA1, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_010612:61131556113155613265419500Mycobacterium marinum M, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_011992:77390577390579750923605Acidovorax ebreus TPSY, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_020133:57106615710661573224421584Mycobacterium liflandii 128FXT, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_008278:81866*8186610216620301Frankia alni ACN14a, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_008148:30248673024867304671521849Rubrobacter xylanophilus DSM 9941, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_015677:3339181*3339181336388124701Ramlibacter tataouinensis TTB310 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_014323:4619344*4619344465241733074Herbaspirillum seropedicae SmR1 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_014318:7821227*7821227785959938373Amycolatopsis mediterranei U32 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg