Query: NC_008593:841291 Clostridium novyi NT, complete genome
Start: 841291, End: 864621, Length: 23331
Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria
General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Start | End | Length | Subject Host Description | E-value | Bit score | Visual BLASTN | Visual BLASTP |
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NC_012563:2979147 | 2979147 | 3002490 | 23344 | Clostridium botulinum A2 str. Kyoto, complete genome | 0 | 654 | BLASTN svg | BLASTP svg |
NC_010723:2735196 | 2735196 | 2753886 | 18691 | Clostridium botulinum E3 str. Alaska E43, complete genome | 1e-147 | 531 | BLASTN svg | BLASTP svg |
NC_010674:2930259 | 2930259 | 2949576 | 19318 | Clostridium botulinum B str. Eklund 17B, complete genome | 2e-142 | 513 | BLASTN svg | BLASTP svg |
NC_008262:1795914 | 1795914 | 1814284 | 18371 | Clostridium perfringens SM101, complete genome | 9e-142 | 511 | BLASTN svg | BLASTP svg |
NC_008261:2117207 | 2117207 | 2140235 | 23029 | Clostridium perfringens ATCC 13124, complete genome | 2e-139 | 504 | BLASTN svg | BLASTP svg |
NC_003366:1901898 | 1901898 | 1924407 | 22510 | Clostridium perfringens str. 13, complete genome | 2e-139 | 504 | BLASTN svg | BLASTP svg |
NC_013192:815854 | 815854 | 838099 | 22246 | Leptotrichia buccalis DSM 1135, complete genome | 7e-84 | 319 | BLASTN svg | BLASTP svg |
NC_010520:2807429 | 2807429 | 2834319 | 26891 | Clostridium botulinum A3 str. Loch Maree, complete genome | 1e-39 | 172 | BLASTN svg | BLASTP svg |
NC_010516:2777205 | 2777205 | 2802419 | 25215 | Clostridium botulinum B1 str. Okra, complete genome | 1e-39 | 172 | BLASTN svg | BLASTP svg |
NC_007681:1300068* | 1300068 | 1324845 | 24778 | Methanosphaera stadtmanae DSM 3091, complete genome | 9e-31 | 143 | BLASTN svg | BLASTP svg |
NC_015636:1477221* | 1477221 | 1502599 | 25379 | Methanothermococcus okinawensis IH1 chromosome, complete genome | 3e-24 | 121 | BLASTN svg | BLASTP svg |
NC_012883:1603744* | 1603744 | 1626510 | 22767 | Thermococcus sibiricus MM 739, complete genome | 3e-24 | 121 | BLASTN svg | BLASTP svg |
NC_003413:181525* | 181525 | 204761 | 23237 | Pyrococcus furiosus DSM 3638, complete genome | 3e-15 | 91.7 | BLASTN svg | BLASTP svg |
NC_015562:627000 | 627000 | 645292 | 18293 | Methanotorris igneus Kol 5 chromosome, complete genome | 5e-14 | 87.7 | BLASTN svg | BLASTP svg |
NC_003106:1435295* | 1435295 | 1456197 | 20903 | Sulfolobus tokodaii str. 7, complete genome | 3e-12 | 81.8 | BLASTN svg | BLASTP svg |
NC_015216:405657 | 405657 | 428274 | 22618 | Methanobacterium sp. AL-21 chromosome, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_015574:2057602* | 2057602 | 2082109 | 24508 | Methanobacterium sp. SWAN-1 chromosome, complete genome | 5e-11 | 77.8 | BLASTN svg | BLASTP svg |
NC_013741:1390823* | 1390823 | 1414804 | 23982 | Archaeoglobus profundus DSM 5631, complete genome | 5e-11 | 77.8 | BLASTN svg | BLASTP svg |
NC_000909:201000* | 201000 | 221133 | 20134 | Methanocaldococcus jannaschii DSM 2661, complete genome | 5e-11 | 77.8 | BLASTN svg | BLASTP svg |
NC_000868:1730820* | 1730820 | 1759564 | 28745 | Pyrococcus abyssi GE5, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_013156:431795* | 431795 | 468843 | 37049 | Methanocaldococcus fervens AG86, complete genome | 1e-08 | 69.9 | BLASTN svg | BLASTP svg |
NC_019977:828427* | 828427 | 853333 | 24907 | Methanomethylovorans hollandica DSM 15978, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_015474:723553* | 723553 | 784015 | 60463 | Pyrococcus sp. NA2 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_014222:186876 | 186876 | 208599 | 21724 | Methanococcus voltae A3 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_014122:393856 | 393856 | 416381 | 22526 | Methanocaldococcus infernus ME chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_004193:2522000 | 2522000 | 2544345 | 22346 | Oceanobacillus iheyensis HTE831, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |