Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2807429 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
280742928122944866hypothetical proteinBLASTP
281236928135921224hypothetical proteinBLASTP
281374528148001056hypothetical proteinBLASTP
28149822815821840hypothetical proteinBLASTP
281612528176601536peptidase M20M25M40 familyQuickGO ontologyBLASTP
28176512818586936putative magnesium and cobalt transport protein CorAQuickGO ontologyBLASTP
281906228196165555-formyltetrahydrofolate cyclo-ligase family proteinQuickGO ontologyBLASTP
28196092820532924HPrSer kinasephosphataseQuickGO ontologyBLASTP
28205642820752189hypothetical proteinBLASTP
28209242821661738DedA family proteinQuickGO ontologyBLASTP
28216272822346720DedA family proteinQuickGO ontologyBLASTP
282245628236011146cysteine-rich domain proteinQuickGO ontologyBLASTP
28236012824599999hypothetical proteinBLASTP
28245772825278702hypothetical proteinBLASTP
28252752825955681glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
28260662826197132hypothetical protein
28263522827326975fructose-16-bisphosphatase class IIQuickGO ontologyBLASTP
28278102827986177hypothetical proteinBLASTP
28280182828419402hypothetical proteinBLASTP
282900428301731170metallo-beta-lactamase family proteinflavodoxinQuickGO ontologyBLASTP
28304872830993507hypothetical proteinBLASTP
28320352832898864nucleoside hydrolase IUNH familyQuickGO ontologyBLASTP
28329162833452537peptide deformylaseQuickGO ontologyBLASTP
28336692834319651V-type ATPase D subunitQuickGO ontologyBLASTP