Pre_GI Gene

Some Help

Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2777205 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
277720527820704866hypothetical proteinBLASTP
278214727833701224hypothetical proteinBLASTP
278352427845791056hypothetical proteinBLASTP
27847712785610840hypothetical proteinBLASTP
278563727871721536peptidase M20M25M40 familyQuickGO ontologyBLASTP
27871632788098936putative magnesium and cobalt transport protein CorAQuickGO ontologyBLASTP
278852527890795555-formyltetrahydrofolate cyclo-ligase family proteinQuickGO ontologyBLASTP
27890722789995924HPrSer kinasephosphataseQuickGO ontologyBLASTP
27900272790215189hypothetical proteinBLASTP
27903862791123738DedA family proteinQuickGO ontologyBLASTP
27910892791808720DedA family proteinQuickGO ontologyBLASTP
279191727930621146cysteine-rich domain proteinQuickGO ontologyBLASTP
27930622794060999hypothetical proteinBLASTP
27940382794739702hypothetical proteinBLASTP
27947392795413675glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
27958152796789975fructose-16-bisphosphatase class IIQuickGO ontologyBLASTP
27972732797449177hypothetical proteinBLASTP
27974812797879399hypothetical proteinBLASTP
279833427995031170metallo-beta-lactamase family proteinflavodoxinQuickGO ontologyBLASTP
27999982800504507hypothetical proteinBLASTP
28015562802419864nucleoside hydrolase IUNH familyQuickGO ontologyBLASTP