Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_007606: Shigella dysenteriae Sd197, complete genome

NCBI: NC_007606

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
11209132122967220541Island text1.5931526.406526.4649Neighbours41BLASTNIslandViewer 1209132.gbk
21515403153810522703Island text1.7433128.932322.3427Neighbours41BLASTN+IslandViewer 1515403.gbk
31999870202709927230Island text3.5328740.583723.9165Neighbours41BLASTN+IslandViewer 1999870.gbk
42353098237552222425Island text1.8471526.839221.7203Neighbours41BLASTNIslandViewer 2353098.gbk
53755155377834323189Island text2.0327933.727230.2412Neighbours41BLASTN+IslandViewer 3755155.gbk
63784847*380859923753Island text2.3211334.147718.2333Neighbours41BLASTNIslandViewer 3784847.gbk
73842708386376421057Island text1.4993929.523325.539Neighbours41BLASTN+3842708.gbk
84182188*420162219435Island text1.5302130.737327.8942Neighbours41BLASTN+IslandViewer PAI DB4182188.gbk