Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:3755155 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
375515537563631209IS1294 ORFQuickGO ontologyBLASTP
37563443756616273hypothetical proteinBLASTP
375687837579181041high-affinity phosphate-specific transport systemQuickGO ontologyBLASTP
375800437590051002high-affinity phosphate-specific transport system cytoplasmic membrane componentQuickGO ontologyBLASTP
37590053759895891high-affinity phosphate-specific transport systemQuickGO ontologyBLASTP
37600783760851774ATP-binding component of high-affinity phosphate-specific transport systemQuickGO ontologyBLASTP
37608663761591726negative regulator for pho regulonQuickGO ontologyBLASTP
376201437636751662hypothetical proteinBLASTP
37639903764493504hypothetical proteinBLASTP
37647363765011276IS1 ORF1QuickGO ontologyBLASTP
37650563765433378IS1 ORF2QuickGO ontologyBLASTP
37665453766883339iso-IS1 ORF2QuickGO ontologyBLASTP
37669413767534594putative lipoproteinQuickGO ontologyBLASTP
376758537687841200hypothetical proteinBLASTP
376933337718402508hypothetical proteinBLASTP
37719293772765837hypothetical proteinBLASTP
377319237748471656L-lactate permeaseQuickGO ontologyBLASTP
37748473775623777transcriptional regulatorQuickGO ontologyBLASTP
377562037768101191L-lactate dehydrogenaseQuickGO ontologyBLASTP
37769963777469474hypothetical proteinBLASTP
37775223778343822serine acetyltransferaseQuickGO ontologyBLASTP