Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:1999870 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
199987020017231854suppressor of ompF assembly mutantsQuickGO ontologyBLASTP
20017762002066291hypothetical proteinBLASTP
20020562002277222hypothetical proteinBLASTP
200261520042371623putative transport proteinQuickGO ontologyBLASTP
20049032005298396iso-IS1 ORF2QuickGO ontologyBLASTP
20055172006410894probable UDP-gal transferaseQuickGO ontologyBLASTP
200678220078671086dTDP-glucose 46 dehydrataseQuickGO ontologyBLASTP
20078672008766900dTDP-6-deoxy-L-mannose-dehydrogenaseQuickGO ontologyBLASTP
20088242009702879glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
20097052010262558dTDP-4-dehydrorhamnose 35-epimeraseQuickGO ontologyBLASTP
201025920114491191putative O-antigen transporterQuickGO ontologyBLASTP
201144620125881143O-antigen polymeraseQuickGO ontology
20125812013429849rhamnosyl transferase IIQuickGO ontologyBLASTP
20134542014365912rhamnosyl transferase IQuickGO ontologyBLASTP
201555120169571407gluconate-6-phosphate dehydrogenaseQuickGO ontologyBLASTP
201720720183731167UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
201846320194971035regulator of length of O-antigen component of lipopolysaccharide chainsQuickGO ontologyBLASTP
20195942020205612phosphoribosyl-amp cyclohydrolaseQuickGO ontologyBLASTP
20201992020975777imidazole glycerol phosphate synthase subunit in heterodimer with HisHQuickGO ontologyBLASTP
20209572021697741N-5-phospho-L-ribosyl-formimino-5-amino-1- 5-phosphoribosyl-4- imidazolecarboxamide isomeraseQuickGO ontologyBLASTP
20216942022284591glutamine amidotransferase subunit of heterodimer with HisFQuickGO ontologyBLASTP
202228420233541071imidazoleglycerolphosphate dehydratasehistidinol-phosphate phosphataseQuickGO ontologyBLASTP
202335120244211071histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
202441820257221305L-histidinalNAD oxidoreductaseQuickGO ontologyBLASTP
20257282026627900ATP phosphoribosyltransferaseQuickGO ontologyBLASTP